Reisner Lab

           Department of Chemistry
           University of Cambridge
           Lensfield Road, Cambridge CB2 1EW, UK
           e-mail: reisner@ch.cam.ac.uk
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Starting Soon

ERC Consolidator Grant on Semi-Artificial Photosynthesis with Wired Enzymes
('MatEnSAP')

This ERC-funded project will start in Summer 2016. It aims to integrate the strengths of natural and artificial photosynthesis to explore novel pathways for efficient solar-to-chemical conversion, which are otherwise inaccessible to either biological or synthetic regimes alone. We thereby address the need for new innovations in the solar fuels field and develop a new chemical biology platform, in which biological pathways can be systematically re-wired in vitro to characterise important metabolic processes, such as bio-hydrogen production.

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Integrating enzymes with artificial scaffolds and electrical circuits. See example - here

Our ‘semi-artificial photosynthetic’ approach will employ enzymes that have been refined by nature to handle electrons, protons and substrates with remarkable specificity, selectivity, and turn-over rates, and wire them together photoelectrochemically using state-of-the-art materials. Central to our approach will be materials design, where materials will be tailored to the dimensions and functions of the enzymes, as well as the development of photo-spectroelectrochemical techniques to deepen our understanding of the enzyme-material interface.

More information about this project will become available at the start of the project.
 
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MatEnSAP - Materials enzyme 'semi-artificial' photosynthesis
   
 
Timeline:

9 December 2015:
ERC Consolidator Grant awarded


Publications leading up to this grant:

“[NiFeSe]-Hydrogenase Chemistry." Wombwell, C.; Caputo, C. A.; Reisner, E. Acc. Chem. Res., 2015, 48, 2858–2865. [html] [pdf]

“Wiring of Photosystem II to Hydrogenase for Photoelectrochemical Water Splitting." Mersch, D.; Lee, C.-Y.; Zhang, J. Z.; Brinkert, K.; Fontecilla-Camps, J. C.; Rutherford, A. W.; Reisner, E. J. Am. Chem. Soc., 2015, 137, 8541–8549. [html] [pdf]

“Carbon Nitride-TiO2 Hybrid Modified with Hydrogenase for Visible Light Driven Hydrogen Production." Caputo, C. A.; Wang, L.; Beranek, R.; Reisner, E. Chem. Sci., 2015, 6, 5690–5694. [html] [pdf]

 “Reversible interconversion of CO2 and formate by a molybdenum-containing formate dehydrogenase.” Bassegoda, A.; Madden, C.; Wakerley, D. W.; Reisner, E.; Hirst, J. J. Am. Chem. Soc., 2014, 136, 15473–15476. [html] [pdf]

Photocatalytic Hydrogen Production using Polymeric Carbon Nitride with a Hydrogenase and a Bioinspired Synthetic Ni Catalyst.” Caputo, C. A.; Gross, M. A.; Lau, V. W.; Cavazza, C.; Lotsch, B. V.; Reisner, E. Angew. Chem. Int. Ed., 2014, 53, 11538–11542. [html] [pdf]

Comparison of photoelectrochemical water oxidation activity of a synthetic photocatalyst system with Photosystem II.” Lai, Y.-H.; Kato, M.; Mersch, D.; Reisner, E. Faraday Discuss., 2014, 176, 199–211. [html] [pdf]

“Protein film photoelectrochemistry of the water oxidation enzyme Photosystem II.” Kato, M.; Zhang, J. Z.; Paul, N.; Reisner, E. Chem. Soc. Rev., 2014, 43, 6485–6497. [html] [pdf]

“Photocatalytic Hydrogen Evolution with a Hydrogenase in a Mediator-Free System under High Levels of Oxygen.” Sakai, T.; Mersch, D.; Reisner, E. Angew. Chem. Int. Ed., 2013, 52, 12313–12316. [html] [pdf]

“Covalent immobilization of oriented photosystem II on a nanostructured electrode for solar water oxidation.” Kato, M.; Cardona, T.; Rutherford, A. W.; Reisner, E. J. Am. Chem. Soc., 2013, 135, 10610–10613. [html] [pdf]

“Photoelectrochemical Water Oxidation with Photosystem II Integrated in a Mesoporous Indium-Tin Oxide Electrode.” Kato, M.; Cardona, T.; Rutherford, A. W.; Reisner, E. J. Am. Chem. Soc.2012, 134, 8332–8335. [html] [pdf]